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B
Christopher Barrett
MD

Curriculum vitae


Surgery Department

UNMC



Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial


Journal article


H. Moore, Christopher D. Barrett, E. Moore, Rashi Jhunjhunwala, R. McIntyre, Peter K. Moore, Janice Wang, N. Hajizadeh, D. Talmor, A. Sauaia, M. Yaffe
Research and Practice in Thrombosis and Haemostasis, 2020

Semantic Scholar DOI PubMedCentral PubMed
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APA   Click to copy
Moore, H., Barrett, C. D., Moore, E., Jhunjhunwala, R., McIntyre, R., Moore, P. K., … Yaffe, M. (2020). Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial. Research and Practice in Thrombosis and Haemostasis.


Chicago/Turabian   Click to copy
Moore, H., Christopher D. Barrett, E. Moore, Rashi Jhunjhunwala, R. McIntyre, Peter K. Moore, Janice Wang, et al. “Study of Alteplase for Respiratory Failure in Severe Acute Respiratory Syndrome Coronavirus 2/COVID‐19: Study Design of the Phase IIa STARS Trial.” Research and Practice in Thrombosis and Haemostasis (2020).


MLA   Click to copy
Moore, H., et al. “Study of Alteplase for Respiratory Failure in Severe Acute Respiratory Syndrome Coronavirus 2/COVID‐19: Study Design of the Phase IIa STARS Trial.” Research and Practice in Thrombosis and Haemostasis, 2020.


BibTeX   Click to copy

@article{h2020a,
  title = {Study of alteplase for respiratory failure in severe acute respiratory syndrome coronavirus 2/COVID‐19: Study design of the phase IIa STARS trial},
  year = {2020},
  journal = {Research and Practice in Thrombosis and Haemostasis},
  author = {Moore, H. and Barrett, Christopher D. and Moore, E. and Jhunjhunwala, Rashi and McIntyre, R. and Moore, Peter K. and Wang, Janice and Hajizadeh, N. and Talmor, D. and Sauaia, A. and Yaffe, M.}
}

Abstract

The coronavirus disease 2019 (COVID‐19) pandemic has caused a large surge of acute respiratory distress syndrome (ARDS). Prior phase I trials (non–COVID‐19) demonstrated improvement in pulmonary function in patients ARDS using fibrinolytic therapy. A follow‐up trial using the widely available tissue‐type plasminogen activator (t‐PA) alteplase is now needed to assess optimal dosing and safety in this critically ill patient population.


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