Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

Journal article

Janice Wang, N. Hajizadeh, E. Moore, R. McIntyre, Peter K. Moore, L. Veress, M. Yaffe, H. Moore, Christopher D. Barrett
Journal of Thrombosis and Haemostasis, 2020

Semantic Scholar DOI PubMedCentral PubMed

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APA Click to copy
Wang, J., Hajizadeh, N., Moore, E., McIntyre, R., Moore, P. K., Veress, L., … Barrett, C. D. (2020). Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series. Journal of Thrombosis and Haemostasis.

Chicago/Turabian Click to copy
Wang, Janice, N. Hajizadeh, E. Moore, R. McIntyre, Peter K. Moore, L. Veress, M. Yaffe, H. Moore, and Christopher D. Barrett. “Tissue Plasminogen Activator (TPA) Treatment for COVID‐19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series.” Journal of Thrombosis and Haemostasis (2020).

MLA Click to copy
Wang, Janice, et al. “Tissue Plasminogen Activator (TPA) Treatment for COVID‐19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series.” Journal of Thrombosis and Haemostasis, 2020.

BibTeX Click to copy

@article{janice2020a,
  title = {Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series},
  year = {2020},
  journal = {Journal of Thrombosis and Haemostasis},
  author = {Wang, Janice and Hajizadeh, N. and Moore, E. and McIntyre, R. and Moore, Peter K. and Veress, L. and Yaffe, M. and Moore, H. and Barrett, Christopher D.}
}

Abstract

A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID‐19 respiratory failure is a relatively preserved lung compliance and high Alveolar‐arterial oxygen gradient, with pathology reports consistently demonstrating diffuse pulmonary microthrombi on autopsy, all consistent with a vascular occlusive etiology of respiratory failure rather than the more classic findings of low‐compliance in ARDS. The COVID‐19 pandemic is overwhelming the world’s medical care capacity with unprecedented needs for mechanical ventilators and high rates of mortality once patients progress to needing mechanical ventilation, and in many environments including in parts of the United States the medical capacity is being exhausted. Fibrinolytic therapy has previously been used in a Phase 1 clinical trial that led to reduced mortality and marked improvements in oxygenation. Here we report a series of three patients with severe COVID‐19 respiratory failure who were treated with tissue plasminogen activator. All three patients had a temporally related improvement in their respiratory status, with one of them being a durable response.